Di-tert-butyl dicarbonate → HCID 11852483, compound

Participants

Reaction Steps

4-tert-Butyl-benzylamine (1.5 eq, 71.91 μl, 0.44 mmol) was added in CH2Cl2 and then BOC2O (1.5 eq, 0.44 mmol, 101.19 μl) and DMAP (0.2 eq, 0.06 mmol, 7.08 mg) were slowly added. After confirming the synthesis of the 1-tert-Butyl-4-isocyanatomethyl-benzene, N-(4-Aminomethyl-2-methyl-6-vinyl-phenyl)-methanesulfonamide (1 eq, 0.29 mmol, 70.5 mg) and TEA (2 eq, 0.58 mmol, 80.84 μl) were added into the reaction mixture. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 9 of example 7 to obtain N-{4-[3-(4-tert-Butyl-benzyl)ureidomethyl]-2-methyl-6-vinylphenyl}methanesulfonamide (29.75 mg, 23.9%).

Provenance & Evidence