Iodine chloride → HCID 26598361, compound

HRID 2358380Notes

Reaction equation

HRID 2358380 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[Cl:10].[I:11]Cl>C(Cl)Cl>[NH2:1][C:2]1[C:9]([I:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[Cl:10]

Participants

4

Reactant 2

HCID 24640Iodine chlorideHCID 5198964-Amino-3-chlorobenzonitrile

Product 1

HCID 26598361HCID 26598361, compoundYield 35.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Amino-3-chloro-benzonitrile (100 mg, 0.66 mmol) and ICl (1.1 eq, 0.72 mmol, 117.05 mg) were added in methylene chloride. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to similar procedure to step 2 of Example 8 to obtain 4-Amino-3-chloro-5-iodobenzonitrile (65.2 mg, 35.80%).

Workup

  1. customThe reaction mixture was purified

Sources & evidence

ORD record
ord-deb5d03a90244b379e2b97896ab2a769
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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