HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine chloride → 4-Amino-3-iodo-5-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine chloride | HCID 24640 | — |
| Reactant | 4-Amino-3-(trifluoromethyl)benzonitrile | HCID 2779488 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Amino-3-iodo-5-(trifluoromethyl)benzonitrile | HCID 68453995 | 18.1% |
Reaction Steps
4-Amino-3-trifluoromethylbenzonitrile (100 mg, 0.54 mmol) and ICl (1.1 eq, 0.58 mmol, 96.00 mg) were added methylene chloride. The mixture was stirred for 12 hr. The reaction mixture was purified according to step 2 of Example 8 to give a title compound (30.5 mg, 18.10%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763657B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-9aac7e94ed4045fb9106760bc2b9cfc2 |
| Source note | uspto-grants-2010_07 |