反应详情

The procedure is similar to that described in Example 4, but starting with 2-amino-7-chloro-1,8-naphthyridine (17.95 g), 2,6-dimethylphenol (48.6 g) and potassium hydroxide pellets (13.2 g; 85% purity). After treatment with caustic soda and washing, the product produced (24.8 g; m.p. 204° C.) is purified by chromatography on a column 45 mm in diameter containing silica (360 g; 0.040-0.063 mm), eluting with pure methylene chloride and collecting 100-cc fractions. After concentration to dryness of fractions 1 to 48 at 40° C. under reduced pressure (4 kPa), 2-amino-7-(2,6-dimethylphenoxy)-1,8 naphthyridine (21.2 g) is produced, m.p. 218° C.

1. washAfter treatment with caustic soda and washing
2. customthe product produced (24.8 g; m.p. 204° C.)
3. customis purified by chromatography on a column 45 mm in diameter
4. additioncontaining silica (360 g; 0.040-0.063 mm)
5. washeluting with pure methylene chloride
6. customcollecting 100-cc fractions
7. concentrationAfter concentration to dryness of fractions 1 to 48 at 40° C. under reduced pressure (4 kPa)