Diethyl Pyrocarbonate → 3-(4-tert-Butylphenyl)propynoic Acid N-[1-(3-fluoro-4-methanesulfonylamino-5-vinylphenyl)ethyl]amide

Participants

Reaction Steps

N-[4-(1-Amino-ethyl)-2-fluoro-6-vinylphenyl]methanesulfonamide (0.03 mmol, 10.0 mg), (4-tert-butylphenyl)propynoic acid (step 2 of Example 11, 0.03 mmol, 6.52 mg), DEPC (0.03 mmol, 5.46 μl), and TEA (0.06 mmol, 8.36 μl) were added into DMF. The mixture was stirred for 12 hr. The reaction mixture was purified according to Example 12 to give a title product (11.3 mg, 95.09%).

Provenance & Evidence