Morpholine → HCID 68454907, compound

Participants

Reaction Steps

Palladium(II) acetate (1.4 mg, 0.006 mmole, 6 mol % eq), rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (7.5 mg, 0.012 mmole, 12 mol % eq), and cesium carbonate (50.3 mg, 0.155 mmole, 1.5 eq) were added into anhydrous toluene. 3-(4-tert-Butyl-2-trifluoromethanesulfonyloxyphenyl)acrylic acid ethyl ester (36.2 mg, 0.103 mmol, 1 eq) in toluene solvent was added by cannula. Morpholine (13.5 μl, 0.155 mmol, 1.5 eq) was added. The mixture was stirred for 12 hr in reflux. After confirming the completion of the reaction with TLC, the reaction mixture was filtered with celite. The filterate was concentrated in vacuo, and then the residue was purified with column chromatography(n-Hx:EA=12:1) to give title product (16.7 mg, 51.2%).

Provenance & Evidence