Cesium carbonate → HCID 68457393, compound

Participants

Reaction Steps

Palladium acetate (2.8 mg, 0.013 mmol, 6% mol eq), rac-2,2′-bis(diphenylphosphino)1,1′-binaphthyl (16.2 mg, 0.026 mmol, 12% mol eq), and cesium carbonate (102.6 mg, 0.315 mmol, 1.5 eq) were added in anhydrous toluene under argon atmosphere. After stirring for 5 min, 3-(4-tert-butyl-2-trifluoromethanesulfonyloxyphenyl)acrylic acid ethyl ester (74.0 mg, 0.210 mmol, 1 eq) and N-Methylpiperazine (34.9 μl, 0.315 mmole, 1.5 eq) were added. The mixture was stirred for 24 hr at 80° C. The reaction mixture was purified according to step 1 of Example 22 to give yellow liquid (50.8 mg, 73.2%).

Provenance & Evidence