Dimethylformamide → HCID 68456100, compound

Participants

Reaction Steps

3-[4-tert-Butyl-2-(2-piperidin-1-yl-ethoxy)phenylacrylic acid (0.039 mmol, 1 eq.), diethylcyanophosphine 7.1 μl (0.0.047 mmol, 1.2 eq), N-(4-aminomethyl-2-fluoro-6-vinylphenyl)-methanesulfonamide 16.8 mg (0.047 mmol, 1.2 eq.), and triethylamine 16.3 μl (0.117 mmol, 3 eq) were added in DMF. The mixture was stirred overnight at room temperature. The reaction mixture was purified according to Example 25 to give solid (32.6 mg, 100%).

Provenance & Evidence