Diethyl Pyrocarbonate → (R)-3-(4-tert-Butylphenyl)-N-[1-(3-fluoro-4-methanesulfonylamino-5-vinylphenyl)ethyl]acrylamide

Participants

Reaction Steps

N-[4-(1-Aminoethyl)-2-fluoro-6-vinylphenyl]methanesulfonamide (0.7 mmol, 25.3 mg), 3-[4-tert-butyl-2-(3-methylbutylamino)phenyl]acrylic acid (0.7 mmol, 15.27 mg), DEPC (0.08 mmol, 12.75 μl), and TEA (0.14 mmol, 19.51 μl) were added in DMF. The reaction mixture was stirred for 12 hrs. The reaction mixture was purified according to similar procedure of Example 21 to yield title product (36.1 mg, 100.0%).

Provenance & Evidence