Diethyl Pyrocarbonate → HCID 68453805, compound

Participants

Reaction Steps

N-(4-Aminomethyl-2-fluoro-6-vinylphenyl)methanesulfonamide (1.1 eq, 0.15 mmol, 53.24 mg), 3-(4-tert-Butylphenyl)-2-fluoroacrylic acid (1 eq, 0.14 mmol, 30 mg), DEPC (1.2 eq, 0.17 mmol, 25.49 μl), and TEA (2 eq, 0.28 mmol, 39.09 μl) were added in DMF under argon atmosphere. The reaction mixture was stirred for 12 hrs. The reaction mixture was purified according to similar procedure of Example 21 to yield title product (30.0 mg, 48%).

Provenance & Evidence