HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-{4-[3-(4-chlorobenzyl)ureidomethyl]-2-vinylphenyl}methane Sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | tert-butyl N-[4-(methanesulfonylamino)-3-vinylbenzyl]carbamate | HCID 68453842 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-{4-[3-(4-chlorobenzyl)ureidomethyl]-2-vinylphenyl}methane Sulfonamide | HCID 57665510 | 14.9% |
Reaction Steps
As described in scheme 12, (4-methanesulfonylamino-3-vinylbenzyl)carbamic acid t-butylester (50 mg, 0.153 mmol) and triethylamine (0.1 ml) and 4-chlorobenzylamine (26 mg) were stirred for one night in the presence of acetonitrile solvent. The solvent was removed from the reaction mixture and purified by column chromatography to yield the purposed compound (9 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763657B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-50948fdbcad541a6a2f96944533ce66a |
| Source note | uspto-grants-2010_07 |