HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(4-t-butylphenyl)-N-[4-(methylsulfonamido)-3-vinylbenzyl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride | HCID 2734059 | — |
| Reactant | 3-(4-Tert-butylphenyl)propanoic acid | HCID 4962173 | — |
| Reactant | N-(4-aminomethyl-2-vinylphenyl)methanesulfonamide | HCID 57665523 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(4-t-butylphenyl)-N-[4-(methylsulfonamido)-3-vinylbenzyl]propanamide | HCID 11852893 | 73% |
Reaction Steps
N-[4-(aminomethyl)-2-vinylphenyl]methanesulfonamide (0.23 mol) and was suspended in methylene chloride and treated with triethylamine followed by 3-(4-tert-butyl-phenyl)-propionic acid and DMTMM (40 mg). The resulting mixture was stirred for 2 days at ambient temperature and concentrated under reduced pressure. The crude residue was column-chromatographed (hexane/ethylacetate=3/2) to yield a white solid (73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763657B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-8565c4098b614421bde48758e68339b3 |
| Source note | uspto-grants-2010_07 |