Iodine → HCID 68454898, compound

HRID 2358421Notes

Reaction equation

HRID 2358421 reaction equation
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][NH:7][C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][CH:13]=2)=[O:9])=[CH:4][C:3]=1[F:24].[I:25]I>[O-]S([O-])(=O)=O.[Ag+].[Ag+].C(O)C>[NH2:1][C:2]1[C:23]([I:25])=[CH:22][C:5]([CH2:6][NH:7][C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:19])([CH3:20])[CH3:21])=[CH:14][CH:13]=2)=[O:9])=[CH:4][C:3]=1[F:24]

Participants

5

Reactant 2

HCID 807IodineHCID 68456140HCID 68456140, compound

Product 1

HCID 68454898HCID 68454898, compound

Reagents, catalysts & solvents 2

HCID 159865Silver sulfateCatalystHCID 702EthanolSolvent

Procedure

To the 50 ml of round bottom flask were put 1-(4-amino-3-fluoro-benzyl)-3-(4-t-butyl-benzyl)-urea (0.25 g, 0.76 mmol) and Ag2SO4 (1.1 eq, 0.26 g) and then cooled to 0° C. And to this mixture was poured 20 ml ethanol and added I2 (1.0 eq, 0.193 g) portionwise and stirred for 3 hours at room temperature. After confirming the completion of the reaction with TLC, the reaction mixture was filtered through celite and concentrated under reduced pressure.

Workup

  1. customTo the 50 ml of round bottom flask were put
  2. customthe completion of the reaction with TLC
  3. filtrationthe reaction mixture was filtered through celite and
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-15cd002eabc14cc790379b98f4d91bf2
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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