Triethylamine → HCID 57665498, compound

Participants

Reaction Conditions

Reaction Steps

N-[4-(1-Aminoethyl)-2-vinylphenyl]methanesulfonamide (236.7 mg, 0.985 mmol, 1 eq.) and Triethylamine (274.6 μl, 1.970 mmol, 2 eq.) were added in methylene chloride. The reaction mixture was cooled down to 0° C. 4-tert-Butylphenyl isocyanate (192.5 μl, 1.083 mmol, 1.3 eq.) was added. The reaction mixture was stirred for 40 min. Methylene chloride was removed in vacuo. The residue was purified with column chromatography (n-Hx:EA=2:1) to yield title compound (155.4 mg, 38%) as white solid.

Provenance & Evidence