Tetrabutylammonium Fluoride → HCID 57665506, compound

Participants

Reaction Conditions

Reaction Steps

(R)—N-(4-{1-[3-(4-tert-Butyl-phenyl)ureido]ethyl}-2-trimethylsilanylethynyl-phenyl)methanesulfonamide (11 mg, 0.023 mmol) was dissolved in THF. The reaction mixture was cooled down to 0° C. 1.0 M solution of tetrabutylammoniumfluoride in THF (0.068 ml, 0.068 mmol, 3 eq.) was added into the reaction mixture. The reaction mixture was stirred for 1.5 hrs. The reaction mixture was concentrated in vacuo and purified with column chromatography (n-Hx:EA=1:1) to yield title compound (7.0 mg, 74%) as a solid.

Provenance & Evidence