1-Tert-butyl-4-isocyanatobenzene → N-{4-[3-(4-tert-Butylphenyl)ureidomethyl]-2-fluoro-6-vinylphenyl}methanesulfonamide

Participants

Reaction Steps

N-(4-Aminomethyl-2-fluoro-6-vinylphenyl)methanesulfonamide (37.8 mg, 0.11 mmol), 1-tert-butyl-4-isocyanatobenzene (1.2 eq, 0.13 mmol, 22.49 μl), and TEA (3 eq, 0.33 mmol, 45.99 μl) were added in methylene chloride. The reaction mixture was stirred for 12 hrs. The reaction mixture was extracted with methylene chloride. A combined organic layer was washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified with column chromatography (n-Hx:EA=1:1) to yield title compound (26.1 mg, 55%) as a white solid.

Provenance & Evidence