1-Tert-butyl-4-isocyanatobenzene → HCID 11853002, compound

Participants

Reaction Steps

Ethenesulfonic acid [4-(1-amino-ethyl)-2-vinyl-phenyl]-amide (15.6 mg, 0.04 mmol), 4-tert-butyl phenylisocyanate (1.2 eq, 0.053 mmol, 9.45 μl), and TEA (1.2 eq, 0.12 mmol, 16.73 μl) were added in MC. The reaction mixture was stirred for 5 hrs. The reaction mixture was extracted with methylene chloride. A combined organic layer was washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified with column chromatography (n-Hx:EA=3:1->2:1) to yield title compound (34.2 mg, 40%).

Provenance & Evidence