Phenylacetylene → HCID 76587260, compound

Participants

Reaction Steps

[1-(4-Amino-3-iodophenyl)ethyl]carbamic acid tert-butyl ester (500 mg, 1.380 mmol, 1 eq.), dichloro(bistriphenylphosphine) palladium (48.4 mg, 0.069 mmol, 0.05 eq.) and copper iodide 13.1 mg (0.069 mmol, 0.05 eq.) were added in THF. After stirring for 30 min at room temperature, TEA (577.0 μl, 4.140 mmol, 3 eq) and phenylacetylene (197.0 μl, 1.794 mmol, 1.3 eq) were added into the reaction mixture. The reaction mixture was stirred overnight with reflux. A reaction solvent was removed in vacuo. The residue was purified with column chromatography (n-Hx:EA=5:1) to yield title compound (452.7 mg) as a yellow liquid.

Provenance & Evidence