1-Tert-butyl-4-isocyanatobenzene → HCID 68455943, compound

Participants

Reaction Conditions

Reaction Steps

N-[4-(1-Aminoethyl)-2-phenylethynylphenyl]methanesulfonamide (440.1 mg, 1.40 mmol) and TEA (390.3 μl, 2.800 mmol, 2 eq) were added in methylene chloride. The reaction mixture was cooled down to 0° C. 4-tert-Butylphenyl isocyanate (248.8%, 1.540 mmol, 1.3 eq.) was added into the mixture. The reaction mixture was stirred for 1 hr. Methylene chloride was removed in vacuo. The residue was purified with column chromatography (n-Hx:EA=2:1) to yield title compound (241.4 mg, 35%) as a solid.

Provenance & Evidence