Ethanol → HCID 13579413, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is similar to that described in Example 1, but starting with 2-thiophenecarboxylic acid (9 g), N,N'-carbonyldiimidazole (11.3 g) and 2-amino-7-chloro-1,8-naphthyridine (9.5 g). The product produced by precipitation in water (9.6 g; m.p. 242° C.) is dissolved in boiling ethanol (700 cc). After 1 hour's cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (2×25 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)-2-thiophenecarboxamide (7.5 g) is produced, m.p. 244° C.

Provenance & Evidence