Hydrochloric Acid → 7-methyl-8H-1,8-naphthyridin-4-one

Participants

Reaction Steps

A solution of the product from Example 1b (1.30 g, 5.59 mmol) and NaOH (233 mg, 5.82 mmol) in 20 mL of water was heated in a sealed metal reactor at 180° C. for 16 h. Cooled to room temperature and adjusted to pH 6 with 1N HCl. The resulting precipitates was filtered and dried under vacuum giving the title compound as a black solid (743 mg, 82%).

Provenance & Evidence