Stannous Chloride → 4-(2-Amino-4-methyl-phenylsulfanyl)-phenol

HRID 2358546Notes

Reaction equation

HRID 2358546 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[C:4]([N+:16]([O-])=O)[CH:3]=1.Cl[Sn]Cl>>[NH2:16][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 549110984-(4-Methyl-2-nitro-phenylsulfanyl)-phenol

Product 1

HCID 668081234-(2-Amino-4-methyl-phenylsulfanyl)-phenolYield 117.5%

Procedure

The product from Example 4b (8.65 g, 31.3 mmol) was reduced with SnCl2 following the procedure from Example 1f giving the title compound as a white solid (8.51 g, 100%).

Sources & evidence

ORD record
ord-7bc2d3d1bdda4e48a6452f660f189d2c
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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