Methanol → HCID 20217523, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is similar to that described in Example 1, but starting with 2-thiophenecarboxylic acid (4 g), N,N'-carbonyldiimidazole (5.1 g) and 2-amino-7-chloro-1,8-naphthyridine (7 g). The product produced by precipitation in water (8.8 g; m.p. 175° C.) is dissolved in boiling methanol (150 cc). After 3 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with methanol (3×10 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-phenoxy-1,8-naphthyridin-2-yl)-2-thiophenecarboxamide (6 g) is produced, m.p. 176° C.

Provenance & Evidence