Stannous Chloride → N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide

HRID 2358567Notes

Reaction equation

HRID 2358567 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)=[C:4]([N+:19]([O-])=O)[CH:3]=1.Cl[Sn]Cl>>[NH2:19][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 66808408N-[4-(4-Methyl-2-nitro-phenylsulfanyl)-phenyl]-acetamide

Product 1

HCID 43168935N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamideYield 100%

Procedure

The product from Example 18a (0.30 gm, 1 mmol) was reacted with SnCl2 as described in Example 1f to give the title compound (0.27 gm, 100%) as an amber oil which was used without further purification.

Sources & evidence

ORD record
ord-93dc182f73a14b1f9b171e9cae0bf9ca
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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