反应详情

温度

4 °C

The procedure is similar to that described in Example 1, but starting with 3-furancarboxylic acid (7.5 g), N,N'-carbonyldiimidazole (10.9 g) and 2-amino-7-phenoxy-1,8-naphthyridine (11.9 g). The product produced by precipitation in water (13 g; m.p. approximately 90° C.) is dissolved in boiling acetonitrile (80 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (2×10 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-Phenoxy-1,8-naphthyridin-2-yl)-3-furancarboxamide (10.7 g) is produced, m.p. 102° C.

1. dissolutionis dissolved
2. customthe crystallised solid is separated by filtration
3. washwashed with acetonitrile (2×10 cc)
4. customdried at 40° C. under reduced pressure (0.067 kPa)