5-Chloro-2-methyl-1,8-naphthyridine → HCID 68460795, compound

HRID 2358614Notes

Reaction equation

HRID 2358614 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:12])=[N:7]2.[CH2:13]([O:15][C:16](=[O:33])[C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:19]([N+:30]([O-])=O)[CH:18]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:33])[C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[C:19]([NH:30][C:2]2[C:3]3[C:8](=[N:7][C:6]([CH3:12])=[CH:5][CH:4]=3)[N:9]=[CH:10][CH:11]=2)[CH:18]=1)[CH3:14]

Participants

3

Reactant 2

HCID 122663725-Chloro-2-methyl-1,8-naphthyridineHCID 68458106HCID 68458106, compound

Product 1

HCID 68460795HCID 68460795, compound

Procedure

The product from Example 1d (2.06 g, 1.16 mmol) was reacted with the Product from Example 53b (3.18 g, 1.16 mmol) for 5 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the trifluoroacetic acid salt (3.61 g, 59%).

Sources & evidence

ORD record
ord-c055124c391347859a7f17591702c9ce
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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