1,2,3,6-Tetrahydropyridine → HCID 20217527, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-7-phenoxycarbonylamino-1,8-naphthyridine (15 g) in anhydrous tetrahydrofuran (500 cc), anhydrous acetonitrile (500 cc) and 1,2,5,6-tetrahydropyridine (4.2 g) are added. The mixture is heated under reflux for 45 minutes. The solution is concentrated under reduced pressure (4 kPa) to a volume of 100 cc. After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (3×15 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)-1,2,5,6-tetrahydropyridine-1-carboxamide (10.5 g) is produced, m.p. 173° C.

Provenance & Evidence