Stannous Chloride → N-[3-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide

HRID 2358633Notes

Reaction equation

HRID 2358633 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[CH:12]=[CH:13][CH:14]=2)=[C:4]([N+:19]([O-])=O)[CH:3]=1.Cl[Sn]Cl>>[NH2:19][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=1[S:8][C:9]1[CH:10]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 68459008N-[3-(4-Methyl-2-nitro-phenylsulfanyl)-phenyl]-acetamide

Product 1

HCID 68458446N-[3-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamideYield 20%

Procedure

The product from Example 71b was reduced with SnCl2 following the procedure from Example 1f providing the title compound (120 mg, 20%).

Sources & evidence

ORD record
ord-b6535fbe37574821896781bf164efe62
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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