Methanesulfonyl chloride → HCID 86615492, compound

Participants

Reaction Steps

The product from Example 6 (100 mg, 0.228 mmol) was reacted with methane sulfonyl chloride (28 mg, 0.251 mmol), N,N-diisopropylethylamine (88.4 mg, 0.684 mmol), and catalytic DMAP in CH2Cl2 for 18 h giving the crude title compound which was purified by HPLC with TFA providing the product as the trifluoroacetic acid (20 mg, 15%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.97 (t, J=7.35 Hz, 3 H) 1.77-1.90 (m, 2 H) 2.40 (s, 3 H) 2.98 (t, J=7.54 Hz, 2 H) 3.43 (s, 3 H) 6.34 (d, J=6.99 Hz, 1 H) 7.19 (d, 2 H) 7.27 (d, 2 H) 7.36-7.40 (m, 2 H) 7.48 (d, 1 H) 7.78 (d, J=8.82 Hz, 1 H) 8.39 (d, J=6.99 Hz, 1 H) 8.91 (d, J=8.46 Hz, 1 H); MS (DCI NH3+) 480 m/z (M+H)+.

Provenance & Evidence