Ethanol → HCID 68460914, compound

Participants

Reaction Steps

The product from Example 85b (0.155 g, 0.57 mmol) was reacted with the product from Example 2g as a 3.15M solution in ethanol (0.18 mL, 0.57 mmol) for 24 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (0.180 g, 56%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.97 (t, J=7.35 Hz, 3 H) 1.72-1.91 (m, 2 H) 2.41 (s, 3 H) 2.75 (d, J=4.41 Hz, 3 H) 2.97 (t, J=7.35 Hz, 2 H) 6.36 (d, J=6.99 Hz, 1 H) 7.20 (d, J=8.46 Hz, 2 H) 7.33-7.47 (m, 2 H) 7.50 (d, 1 H) 7.63 (d, J=8.46 Hz, 2 H) 7.77 (d, J=8.82 Hz, 1 H) 8.30-8.44 (m, J=6.62, 6.62 Hz, 2 H) 8.91 (d, J=8.82 Hz, 1 H) 10.86-11.09 (s, 1 H); MS (ESI+) m/z 443.2 (M+H)+; (ESI−) m/z 441.2 (M−H)−.

Provenance & Evidence