4-Chloro-3-nitrophenol → 4-(3-Bromo-benzyloxy)-1-chloro-2-nitro-benzene

HRID 2358701Notes

Reaction equation

HRID 2358701 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19]Br)[CH:14]=1>>[Br:12][C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][CH:18]=1)[CH2:19][O:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Participants

3

Reactant 2

HCID 691274-Chloro-3-nitrophenolHCID 699793-Bromobenzyl bromide

Product 1

HCID 574698824-(3-Bromo-benzyloxy)-1-chloro-2-nitro-benzene

Procedure

A solution of 4-chloro-3-nitro-phenol was reacted with 1-bromo-3-bromomethyl-benzene using the conditions described in Example 237C to provide 4-(3-Bromo-benzyloxy)-1-chloro-2-nitro-benzene which was treated sequentially using the procedures from Examples 237D and 237E to provide 4-[2-Amino-4-(3-bromo-benzyloxy)-phenylsulfanyl]-phenol.

Sources & evidence

ORD record
ord-04a7082b4aec4c4e8ac2cfa3257634a8
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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