4-Fluorobenzyl bromide → HCID 57469891, compound

HRID 2358707Notes

Reaction equation

HRID 2358707 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 691274-Chloro-3-nitrophenol

Product 1

HCID 57469891HCID 57469891, compound

Procedure

A solution of 4-chloro-3-nitro-phenol was reacted with 1-Bromomethyl-4-fluoro-benzene using the conditions described in Example 237C to provide 1-Chloro-4-(4-fluoro-benzyloxy)-2-nitro-benzene which was treated sequentially using the procedures from Examples 237D and 237E to provide 4-[2-amino-4-(4-fluoro-benzyloxy)-phenylsulfanyl]-phenol.

Sources & evidence

ORD record
ord-b4b1e0854b494aa4a8f3cd9d70b66d9c
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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