Ethanol → HCID 68461764, compound

Participants

Reaction Steps

The product from Example 1d (18 mg, 0.085 mmol) was reacted in ethanol (1 mL) with the product from Example 153a (33 mg, 0.085 mmol) for 18 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (14 mg, 30%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.97 (t, J=7.35 Hz, 3 H) 1.69-1.93 (m, 2 H) 2.02 (s, 3 H) 2.99 (t, J=6.99 Hz, 2 H) 3.75 (s, 3 H) 5.13 (s, 2 H) 6.29 (d, J=7.35 Hz, 1 H) 6.91 (dd, J=8.09, 2.57 Hz, 1 H) 6.95-7.05 (m, 2 H) 7.13 (d, J=8.82 Hz, 2 H) 7.16-7.24 (m, 2 H) 7.31 (t, J=8.09 Hz, 1 H) 7.38 (d, J=8.46 Hz, 1 H) 7.42 (d, J=8.82 Hz, 2 H) 7.80 (d, J=8.82 Hz, 1H) 8.35 (d, J=6.99 Hz, 1 H) 8.97 (d, J=8.82 Hz, 1 H) 9.97 (s, 1 H) 11.00 (s, 1 H) 14.36 (s,1H); MS (ESI+) m/z 565(M+H)+.

Provenance & Evidence