5-Chloro-2-methyl-1,8-naphthyridine → HCID 68456169, compound

HRID 2358736Notes

Reaction equation

HRID 2358736 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:12])=[N:7]2.[NH2:13][C:14]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:15]=1[O:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1>C(O)C>[Cl:28][C:26]1[CH:25]=[CH:24][C:15]([O:16][C:17]2[CH:18]=[CH:19][C:20]([OH:23])=[CH:21][CH:22]=2)=[C:14]([NH:13][C:2]2[C:3]3[C:8](=[N:7][C:6]([CH3:12])=[CH:5][CH:4]=3)[N:9]=[CH:10][CH:11]=2)[CH:27]=1

Participants

4

Reactant 2

HCID 122663725-Chloro-2-methyl-1,8-naphthyridineHCID 66664995HCID 66664995, compound

Product 1

HCID 68456169HCID 68456169, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from Example 1d (80 mg, 4.5 mmol) was reacted with the product from Example 165c (106 mg, 4.5 mmol) in ethanol (15 mL) at 85° C. in a sealed tube for 18 h giving the crude title compound which was purified by HPLC with TFA providing the product as the trifluoroacetic acid (40 mg, 18%).

Sources & evidence

ORD record
ord-3c4c191f8cb14222ba3f1f8098cd432b
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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