Aluminium lithium hydride → HCID 68461613, compound

Participants

Reaction Steps

The product of Example 167c (88 mg, 0.175 mmol) was reacted with lithium aluminum hydride (13.3 mg, 0.351 mmol) in THF (5 mL) at 60° C. for 15 h giving the crude title compound which was purified by HPLC with TFA providing the product as the trifluoroacetic acid (15 mg, 14%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 11.04 (s, 1 H) 8.92 (d, J=8.82 Hz, 1 H) 8.54 (d, J=6.99 Hz, 1 H) 8.18 (s, 2 H) 7.72-7.80 (m, 2 H) 7.59 (dd, J=9.01, 2.76 Hz, 1 H) 7.40 (d, J=8.82 Hz, 2 H) 6.99-7.12 (m, 3 H) 6.74 (d, J=6.99 Hz, 1 H) 3.97 (q, J=5.52 Hz, 2 H) 2.74 (s, 3 H); MS (ESI+) m/z 391 (M+H)+.

Provenance & Evidence