Sodium borohydride → HCID 68458743, compound

Participants

Reaction Steps

To the product from Example 170a (1.8 g, 6.2 mmol) in ethanol (50 mL) was added sodium borohydride (0.32 g, 8.64 mmol) portion wise. The reaction was stirred at room temperature for 16 h. The excess sodium borohydride was destroyed by addition of acetic acid. The reaction was poured onto ice/water and extracted with ethyl acetate. The organic phase washed with water, brine, and dried over sodium sulfate, filtered and concentrated under vacuum giving the title compound. The crude residue was purified by silica gel chromatography eluting with (hexanes/ethyl acetate/methanol (75:15:5) to give the desired product (0.98 g, 54%).

Provenance & Evidence