Potassium Hydroxide → HCID 23699128, compound

HRID 235875Notes

Reaction equation

HRID 235875 reaction equation
[OH-].[K+:2].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([C:21]3[O:22][CH:23]=[CH:24][CH:25]=3)=[C:13]([CH2:15][C:16]([O:18]CC)=[O:17])[N:14]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([C:21]3[O:22][CH:23]=[CH:24][CH:25]=3)=[C:13]([CH2:15][C:16]([O-:18])=[O:17])[N:14]=2)=[CH:6][CH:5]=1.[K+:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 139577TA 1801

Product 1

HCID 23699128HCID 23699128, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.4 g of potassium hydroxide in 30 ml of methanol is added to 1.0 g of ethyl 2-[2-(4-chlorophenyl)-5-(2-furyl)-4-oxazolyl]acetate at 5° to 10° C. The mixture is stirred at room temperature for 10 hours. Then, the precipitates are collected by filtration, washed with ether and then dried. 0.85 g of potassium 2-[2-(4-chlorophenyl)-5-(2-furyl)-4-oxazolyl]acetate is obtained. Yield: 80.2%

Workup

  1. filtrationThen, the precipitates are collected by filtration
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-79503de5d6a34a75a1079102c373133d
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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