HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 68457779, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-((Tert-butyldimethylsilyl)oxy)aniline | HCID 14314782 | — |
| Reactant | 3-(4-Chloro-2-nitro-phenoxy)-benzoyl chloride | HCID 86615500 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68457779 | HCID 68457779 | 85% |
Reaction Steps
To the product from Example 168b (1.3 g, 4.2 mmol) in THF (25 mL) was added 3-(tert-Butyl-dimethyl-silanyloxy)-phenylamine (1.0 g, 4.2 mmol), and N,N-diisopropylethylamine (0.67 g, 5.2 mmol). The reaction was stirred for 16 h. The reaction was poured into water and extracted with ethyl acetate. The organic layer washed with 5% HCL, water, brine, and dried over sodium sulfate, filtered and concentrated under vacuum giving the title compound (1.3 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763731B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-14434b1ca3d440328513cbbf3a49c918 |
| Source note | uspto-grants-2010_07 |