Methanol → HCID 13392286, compound

HRID 235876Notes

Reaction equation

HRID 235876 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.CO.[OH-].[Na+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 13361433HCID 13361433, compound

Product 1

HCID 13392286HCID 13392286, compoundYield 87.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.0 g of ethyl 2-[2-(4-fluorophenyl)-5-(2-furyl)-4-oxazolyl]acetate, 70 ml of methanol, 10 ml of water and 1.5 g of sodium hydroxide are treated in the same manner as described in Example 16. 4.0 g of 2-[2-(4-fluorophenyl)-5-(2-furyl)-4-oxazolyl]acetic acid are thereby obtained. Yield: 87.7%

Sources & evidence

ORD record
ord-bd97933c676747fd8645cfe1ad29a918
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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