Acetyl chloride → HCID 68457970, compound

HRID 2358773Notes

Reaction equation

HRID 2358773 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:19](=[O:21])[CH3:20])=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 68459495HCID 68459495, compound

Product 1

HCID 68457970HCID 68457970, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The material from Example 185a (0.990 3.80 mmol) was dissolved in CH2Cl2 to which acetyl chloride (0.328 g, 4.183 mmol) was added. Reaction mixture stirred at room temperature for 1 hr at which time the title compound was collected by filtration (910 mg, 79%).

Workup

  1. additionwas added
  2. customReaction mixture

Sources & evidence

ORD record
ord-7de8da62b13c479ab4b6b62528a85936
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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