Sodium Hydroxide → HCID 68459004, compound

HRID 2358783Notes

Reaction equation

HRID 2358783 reaction equation
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[C:14]([Cl:21])[CH:13]=2)=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[Cl:21][C:14]1[CH:13]=[C:12]([CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=1)[O:11][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:22])=[O:2])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68456873HCID 68456873, compound

Product 1

HCID 68459004HCID 68459004, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product from Example 195a (2.50 g, 13.5 mmol) and 2N NaOH (7.77 ml, 15.5 mmol) in MeOH (25 mL) was refluxed for 1 hour, and then evaporated. The residue was dissolved in H2O and acidified to pH 2 with 10% HCl under stirring. The precipitate was collected by filtration, washed with H2O, and dried in vacuum overnight to give the title compound as pale brown crystal (2.30 g, 62%).

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in H2O
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with H2O
  5. customdried in vacuum overnight

Sources & evidence

ORD record
ord-34d2ee4dddcd4909b14996d4d784bbe1
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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