HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2358795Generated: October 30, 2026
5-Chloro-2-propyl-[1,8]naphthyridine → N-{3-[4-Methyl-2-(7-propyl-[1,8]naphthyridin-4-ylamino)-phenylsulfanyl]-phenyl}-acetamide
https://huagongshe.com/reaction/2358795
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Chloro-2-propyl-[1,8]naphthyridine | HCID 44140176 | — |
| Reactant | N-[3-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide | HCID 68458446 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-{3-[4-Methyl-2-(7-propyl-[1,8]naphthyridin-4-ylamino)-phenylsulfanyl]-phenyl}-acetamide | HCID 68456178 | 74.7% |
Reaction Steps
The title compound was prepared from the product of Example 2g (750 mg, 3.63 mmol), and the product of Example 199c (988 mg, 3.63 mmol) combined in 10 mL of EtOH and heated to 80° C. for 40 hrs. After cooling to room temperature the solvent was removed under vacuum giving the title compound (1.2 g, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07763731B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-5fc249ebf6bd4add8fdda8d6ee19a554 |
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| Source note | uspto-grants-2010_07 |
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