Water → HCID 68460621, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 208c (447 mg, 1.065 mmol) was dissolved in 5 ml of a 1:1 (THF:water) solution. To this was added LiOH (51 mg, 2.129 mmol) and the reaction mixture was heated to 60° C. for 2 h the reaction mixture was then allowed to cool to room temperature and brought to neutral with HOAc. The product was extracted with ethyl acetate. Dried over Na2SO4, filtered and concentrated under vacuum giving the title compound (180 mg, 42%).

Provenance & Evidence