4-Methyl[1,1'-biphenyl]-2-amine → HCID 68457935, compound

Participants

Reaction Steps

The product from Example 2g (0.106 g, 0.49 mmol) was reacted with the product from Example 213b (0.088 g, 0.49 mmol) for 65 h following the procedure of Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (0.122 g, 52%). 1H NMR (300 MHz, DMSO-d6) ppm: 0.96 (t, J=7.35 Hz, 3 H) 1.81 (d, J=7.72 Hz, 2 H) 2.43 (s, 3 H) 2.89-3.02 (m, 2 H) 6.31 (d, J=6.99 Hz, 1 H) 7.14-7.58 (m, 8 H) 7.77 (d, J=8.46 Hz, 1 H) 8.32 (d, J=7.35 Hz, 1 H) 8.91 (d, J=8.46 Hz, 1 H) 10.91-11.08 (m, 1 H); MS (ESI+) m/z 354.0 (M+H)+; (ESI−) m/z 351.9 (M−H)−.

Provenance & Evidence