5-Chloro-2-methyl-1,8-naphthyridine → HCID 68459957, compound

Participants

Reaction Steps

The product from Example 1d (0.065 g, 0.36 mmol) was reacted with the product from Example 217b (0.072 g, 0.34 mmol) for 96 h at 100° C. following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing a trifluoroacetic acid salt (0.102 gm, 64%). 1H NMR (300 MHz, DMSO-d6) ppm: 2.43 (s, 3 H) 2.72 (s, 3 H) 3.62 (s, 3 H) 6.29 (d, J=7.35 Hz, 1 H) 6.77 (dd, J=7.91, 2.02 Hz, 1 H) 6.87-7.00 (m, 2 H) 7.17 (t, J=7.91 Hz, 1 H) 7.36 (s, 1 H) 7.41-7.46 (m, 1 H) 7.51-7.56 (m, 1 H) 7.75 (d, J=8.46 Hz, 1 H) 8.32 (d, J=7.35 Hz, 1 H) 8.91 (d, J=8.82 Hz, 1 H) 11.99-12.22 (s, 1 H); MS (ESI+) m/z 356.0 (M+H)+; (ESI−) m/z 354.0 (M−H)−.

Provenance & Evidence