5-Chloro-2-methyl-1,8-naphthyridine → HCID 68456166, compound

Participants

Reaction Steps

The product of Example 227b (60 mg, 0.278 mmol) was reacted with the product from Example 1d (50 mg, 0.278 mmol) for 16 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid (24 mg, 28%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.44 (s, 3 H), 2.73 (s, 3 H), 6.45 (d, J=6.99 Hz, 1 H), 7.02-7.12 (m, J=7.72, 1.10 Hz, 2 H), 7.40-7.49 (m, 2 H), 7.50-7.58 (m, J=1.84 Hz, 1 H), 7.72 (dd, J=8.46, 3.31 Hz, 2 H), 8.21-8.27 (m, J=2.94, 0.74 Hz, 1 H), 8.38 (d, J=6.99 Hz, 1 H), 8.85 (d, J=8.82 Hz, 1 H), 10.99 (s, 1 H); MS (ESI+) m/z 359 (M+H−TFA)+; (ESI−) m/z 357 (M−H−TFA)−.

Provenance & Evidence