Tazobactam → HCID 178429814, compound

HRID 2358938Notes

Reaction equation

[CH3:1][C@@:2]1([CH2:15][N:16]2[N:20]=[N:19][CH:18]=[CH:17]2)[S:6](=[O:8])(=[O:7])[C@@H:5]2[CH2:9][C:10](=[O:11])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28]>>[CH3:1][C@@:2]1([CH2:15][N:16]2[N:20]=[N:19][CH:18]=[CH:17]2)[S:6](=[O:7])(=[O:8])[C@@H:5]2[CH2:9][C:10](=[O:11])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:28])[NH2:29]

Participants

Reactant 2

HCID 123630Tazobactam

HCID 178418600HCID 178418600, compound

Product 1

HCID 178429814HCID 178429814, compound

Procedure

The 1H-NMR spectrum (FIG. 7) of polymorph Ia indicates a stoichiometry of 1:1 tazobactam acid:arginine.

Sources & evidence

ORD record: ord-a80b731756c6451eb8ea3cc06d08d764
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08685957B1

Reaction notes

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