N-(2-chloroethyl)-2-methyl-3-hydroxy-4-pyridinone → N-(4-propargylpiperazin-1-ylethyl)-2-methyl-3-hydroxy-4-pyridinone

Participants

Reaction Steps

The title compound was prepared as described in Scheme D by reaction of N-(2-chloroethyl)-2-methyl-3-hydroxy-4-pyridinone (H2, Appendix VII) (prepared as described in Bijaya L. Rai, Lotfollah Dekhordi, Hicham Khodr, Yi Jin, Zudong Liu, and Robert C. Hider J. Med. Chem. 1998, 41, 3347-3359) with N-propargylpiperazine (obtained as in step (iii) in Example 2):

Provenance & Evidence