N-bromobutanimide → HCID 66911312, compound

HRID 2358960Notes

Reaction equation

HRID 2358960 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]2[CH:10]([CH:11]=1)[NH:9][C:8](=[O:12])[CH2:7][CH2:6]2.C1C(=O)N([Br:20])C(=O)C1>>[Br:20][C:3]1[C:2]([F:1])=[CH:11][CH:10]2[CH:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)[CH:4]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 669113097-fluoro-3,4,4a,8a-tetrahydro-1H-quinolin-2-one

Product 1

HCID 66911312HCID 66911312, compound

Procedure

This intermediate was obtained according to general procedure I from 7-fluoro-3,4,4a,8a-tetrahydro-1H-quinolin-2-one (92 mg, 0.56 mmol) and NBS (104 mg, 0.58 mmol) after flash chromatography on silica gel (hexanes/ethyl acetate, 5/1, Rf=0.27) as white solid (120 mg, 0.49 mmol, 88%).

Workup

  1. customThis intermediate was obtained

Sources & evidence

ORD record
ord-ad96ac6b595544b0b13e99a7b239694c
Source dataset
uspto-grants-2014_04
Patent number
US08685960B2

Reaction notes

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