Chloroacetyl chloride → N-(4-bromo-2-nitrophenyl)-2-chloroacetamide

HRID 2358964노트

반응식

HRID 2358964 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15]>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:14](=[O:15])[CH2:13][Cl:12])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 701324-Bromo-2-nitroaniline

생성물 1

HCID 16457083N-(4-bromo-2-nitrophenyl)-2-chloroacetamide수율 96%

실험 절차

To a solution of 4-bromo-2-nitroaniline (15.0 g, 69.1 mmol) was added drop wise 2-chloroacetyl chloride (9.4 g, 82.9 mmol) under nitrogen. After refluxing for 1.5 h, the reaction mixture was cooled to ambient temperature and the solvent was removed under reduced pressure. Crystallization from ethyl acetate/hexane afforded N-(4-bromo-2-nitrophenyl)-2-chloroacetamide (19.4 g, 66.1 mmol, 96%) as yellow needles.

후처리

  1. temperatureAfter refluxing for 1.5 h
  2. customthe solvent was removed under reduced pressure
  3. customCrystallization from ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-6b18f54503354054bfb456e3d85ac79e
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08685960B2

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